Septic Shock Surveillance

Septic Shock

Pediatric severe sepsis and septic shock continue to be significant causes of childhood morbidity and mortality worldwide. The following review will highlight some of the controversies surrounding the consensus definitions. It will chronicle recent clinical and translational research, focusing on pediatric sepsis-specific challenges investigators face. It will also address the pathophysiology o...

Septic shock.

Septic shock, the most severe complication of sepsis, is a deadly disease. In recent years, exciting advances have been made in the understanding of its pathophysiology and treatment. Pathogens, via their microbial-associated molecular patterns, trigger sequential intracellular events in immune cells, epithelium, endothelium, and the neuroendocrine system. Proinflammatory mediators that contrib...

vasopressin and septic shock

septic shock continues to be one of the leading causes of death in the intensive care units. when the shock state persists after adequate fluid resuscitation,  vasopressor therapy is required to improve and maintain adequate tissue/organ  perfusion in an attempt to improve survival and prevent the development of multiple organ dysfunction and failure. various studies have suggested that exogeno...

Mycobacterium tuberculosis septic shock.

BACKGROUND Septic shock due to Mycobacterium tuberculosis (MTB) is an uncommon but well-recognized clinical syndrome. The objective of this study was to describe the unique clinical characteristics, epidemiologic risk factors, and covariates of survival of patients with MTB septic shock in comparison with other bacterial septic shock. METHODS A retrospective nested cohort study was conducted ...

Septic Shock in Neonates